The color of Woodhouse's toad ranges from green, greenish gray, gray, tannish gray to brown. It often has a white or tan stripe down the back. There are irregular (not paired) dark brown or black spots on the back with 1–6 “warts” inside each spot. The belly is plain white, but there is sometimes a single breast spot. The oblong parotoid gland is connected to a rather prominent bony crest on the head. Call is a short, nasal “w-a-a-ah,” lasting from 1 to 2½ seconds, similar to the call of the Fowler’s toad, but with a slightly lower pitch.
Similar species: Fowler’s toad used to be considered a subspecies of Woodhouse’s toad. It occurs in different parts of the state, usually has a dark gray spot on the chest, and its oblong parotoid gland is connected to a rather shallow bony crest on the head. Woodhouse’s toad can hybridize with the eastern American toad. Where this happens, intermediate characteristics will occur.